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Do you know everything about topical NSAIDs?
What is True and what is a Myth? Find out by playing this game with 3 levels of increasing difficulty. At level 2 you will have a time limit, but you also get help: a second chance. Level 3 goes deeper into the science, and when you solve it, you become the Mythbuster Master. Good luck!
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Topical NSAIDs are as effective as oral NSAIDs for musculoskeletal pain.
LEVEL 1
Topical vs oral NSAIDs
Topical vs oral NSAIDs
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Good answer!
Topical NSAIDs can be considered to have similar efficacy as oral NSAIDs for musculoskeletal injuries*.
*Klinge SA, Sawyer GA S. Effectiveness and safety of topical versus oral nonsteroidal anti-inflammatory drugs: a comprehensive review. 41(2):64-74, 2013.
*Klinge SA, Sawyer GA S. Effectiveness and safety of topical versus oral nonsteroidal anti-inflammatory drugs: a comprehensive review. 41(2):64-74, 2013.
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YOU HAVE LOST :(
Topical NSAIDs can be considered to have similar efficacy as oral NSAIDs for musculoskeletal injuries*.
*Klinge SA, Sawyer GA S. Effectiveness and safety of topical versus oral nonsteroidal anti-inflammatory drugs: a comprehensive review. 41(2):64-74, 2013.
*Klinge SA, Sawyer GA S. Effectiveness and safety of topical versus oral nonsteroidal anti-inflammatory drugs: a comprehensive review. 41(2):64-74, 2013.
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Topical NSAIDs have a similar tolerability profile with placebo.
LEVEL 1
Topical vs oral NSAIDs
Topical vs oral NSAIDs
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Low risk of systemic side effects: Topical NSAIDs have a tolerability profile similar to topical placebo*.
*Wiffen PJ, Xia J. Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain. Curr Med Res Opin. 2020 Apr;36(4):637-650.
*Wiffen PJ, Xia J. Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain. Curr Med Res Opin. 2020 Apr;36(4):637-650.
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Good answer!
Low risk of systemic side effects: Topical NSAIDs have a tolerability profile similar to topical placebo*.
*Wiffen PJ, Xia J. Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain. Curr Med Res Opin. 2020 Apr;36(4):637-650.
*Wiffen PJ, Xia J. Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain. Curr Med Res Opin. 2020 Apr;36(4):637-650.
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Topical NSAIDs are only for older people.
LEVEL 1
Topical vs oral NSAIDs
Topical vs oral NSAIDs
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Voltarol Gels can be used from 14 years of age and more broadly topical NSAIDs have been proven to effective across a range of adult age groups, up to and including the elderly1-3.
1. Baraf HS, et al. 2011 Jan 1;28(1):27-4.
2. Bariguian Revel F, et al. 2020 Jun;7(2):217-36
3. Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
PI available at the bottom of the page.
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Good answer!
Voltarol Gels can be used from 14 years of age and more broadly topical NSAIDs have been proven to effective across a range of adult age groups, up to and including the elderly1-3.
1. Baraf HS, et al. 2011 Jan 1;28(1):27-4.
2. Bariguian Revel F, et al. 2020 Jun;7(2):217-36
3. Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
PI available at the bottom of the page.
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All topical NSAIDs are created equally (are the same).
15
LEVEL 2
Topical NSAIDs
Topical NSAIDs
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Good answer!
Not all topical NSAIDs are the same. The active ingredient matters, but so does the gel or cream formulation so it can provide effective delivery of the active ingredient to the site of pain*.
*Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
*Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
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Wrong answer!
Not all topical NSAIDs are the same. The active ingredient matters, but so does the gel or cream formulation so it can provide effective delivery of the active ingredient to the site of pain*.
*Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
*Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
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TIME IS UP :(
It's a myth!
Not all topical NSAIDs are the same. The active ingredient matters, but so does the gel or cream formulation so it can provide effective delivery of the active ingredient to the site of pain*.
*Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
*Derry S et al. Cochrane Database Sys Rev 2015; 6: CD007402
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15
Topical diclofenac has a targeted effect on inflammation and thus combats one of the causes of pain.
LEVEL 2
Topical NSAIDs
Topical NSAIDs
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Good answer!
Topical diclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that fights inflammation, a cause of pain at the site of pain, by inhibiting prostaglandin biosynthesis through its predominant effect on the enzyme COX-2*.
*Brune K. Curr Med Res Opin 2007;23:2985–95.
*Brune K. Curr Med Res Opin 2007;23:2985–95.
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Wrong answer!
Topical diclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that fights inflammation, a cause of pain at the site of pain, by inhibiting prostaglandin biosynthesis through its predominant effect on the enzyme COX-2*.
*Brune K. Curr Med Res Opin 2007;23:2985–95.
*Brune K. Curr Med Res Opin 2007;23:2985–95.
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TIME IS UP :(
It's a truth!
Topical diclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that fights inflammation, a cause of pain at the site of pain, by inhibiting prostaglandin biosynthesis through its predominant effect on the enzyme COX-2*.
*Brune K. Curr Med Res Opin 2007;23:2985–95.
*Brune K. Curr Med Res Opin 2007;23:2985–95.
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Diclofenac has similar potency vs other NSAIDs.
15
LEVEL 2
Topical NSAIDs
Topical NSAIDs
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Good answer!
Compared to other NSAIDs such as ibuprofen, diclofenac shows a pronounced potency in its inhibition of the COX-2 enzyme*.
*Rao P, Knaus EE. J Pharm Sci 2008;11:81s–110s.
PI available at the bottom of the page.
PI available at the bottom of the page.
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Wrong answer!
Compared to other NSAIDs such as ibuprofen, diclofenac shows a pronounced potency in its inhibition of the COX-2 enzyme*.
*Rao P, Knaus EE. J Pharm Sci 2008;11:81s–110s.
PI available at the bottom of the page.
PI available at the bottom of the page.
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TIME IS UP :(
It's a myth!
Compared to other NSAIDs such as ibuprofen, diclofenac shows a pronounced potency in its inhibition of the COX-2 enzyme*.
*Rao P, Knaus EE. J Pharm Sci 2008;11:81s–110s.
PI available at the bottom of the page.
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Voltarol gel does not penetrate deep enough through the skin to be effective
9
LEVEL 3
Voltarol gel
Mode of Action
Voltarol gel
Mode of Action
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TIME IS UP :(
It's a myth!
Voltarol gel is clinically proven to demonstrate deep penetration into the joint*.
After topical administration, diclofenac is distributed to the subcutaneous tissues, muscle, synovial tissues and synovial fluid^.
*Seefried et al. Ther Adv Musculoskel Dis. 2020;12:1-13.
^Hagen M, Baker M. Curr Med Res Opin 2017;33:1623–34.
PI available at the bottom of the page.
^Hagen M, Baker M. Curr Med Res Opin 2017;33:1623–34.
PI available at the bottom of the page.
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Good answer!
Voltarol gel is clinically proven to demonstrate deep penetration into the joint*.
After topical administration, diclofenac is distributed to the subcutaneous tissues, muscle, synovial tissues and synovial fluid^.
After topical administration, diclofenac is distributed to the subcutaneous tissues, muscle, synovial tissues and synovial fluid^.
*Seefried et al. Ther Adv Musculoskel Dis. 2020;12:1-13.
^Hagen M, Baker M. Curr Med Res Opin 2017;33:1623–34.
PI available at the bottom of the page.
^Hagen M, Baker M. Curr Med Res Opin 2017;33:1623–34.
PI available at the bottom of the page.
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Wrong answer!
Voltarol gel is clinically proven to demonstrate deep penetration into the joint*.
After topical administration, diclofenac is distributed to the subcutaneous tissues, muscle, synovial tissues and synovial fluid^.
After topical administration, diclofenac is distributed to the subcutaneous tissues, muscle, synovial tissues and synovial fluid^.
*Seefried et al. Ther Adv Musculoskel Dis. 2020;12:1-13.
^Hagen M, Baker M. Curr Med Res Opin 2017;33:1623–34.
PI available at the bottom of the page.
^Hagen M, Baker M. Curr Med Res Opin 2017;33:1623–34.
PI available at the bottom of the page.
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Voltarol 2.32% gel builds a reservoir in the epidermis and dermis which expands over time.
9
LEVEL 3
Voltarol gel
Mode of Action
Voltarol gel
Mode of Action
2
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TIME IS UP :(
It's a truth!
Voltarol 2.32% gel is proven to build a reservoir of diclofenac which gradually expands in size in the epidermis and into the deep dermis; at 24 hours it is 83% larger than 4 hours, post application*^†
*Max daily dose applied in one go, semi-quantitative ToF-SIMS evaluation; in vitro study
^Haleon Data on File 2023
†Belsey NA et al Journal of Controlled Release 2023;364:79-89
PI available at the bottom of the page.
^Haleon Data on File 2023
†Belsey NA et al Journal of Controlled Release 2023;364:79-89
PI available at the bottom of the page.
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Good answer!
Voltarol 2.32% gel is proven to build a reservoir of diclofenac which gradually expands in size in the epidermis and into the deep dermis; at 24 hours it is 83% larger than 4 hours, post application*^†
*Max daily dose applied in one go, semi-quantitative ToF-SIMS evaluation; in vitro study
^Haleon Data on File 2023
†Belsey NA et al Journal of Controlled Release 2023;364:79-89
PI available at the bottom of the page.
^Haleon Data on File 2023
†Belsey NA et al Journal of Controlled Release 2023;364:79-89
PI available at the bottom of the page.
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Wrong answer!
Voltarol 2.32% gel is proven to build a reservoir of diclofenac which gradually expands in size in the epidermis and into the deep dermis; at 24 hours it is 83% larger than 4 hours, post application*^†
*Max daily dose applied in one go, semi-quantitative ToF-SIMS evaluation; in vitro study
^Haleon Data on File 2023
†Belsey NA et al Journal of Controlled Release 2023;364:79-89
PI available at the bottom of the page.
^Haleon Data on File 2023
†Belsey NA et al Journal of Controlled Release 2023;364:79-89
PI available at the bottom of the page.
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Voltarol 2.32% gel provides pain relief as effective as placebo.
9
LEVEL 3
Voltarol gel
Mode of Action
Voltarol gel
Mode of Action
2
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1
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TIME IS UP :(
It's a myth!
Voltarol 2.32% gel is clinically proven to provide 2x more pain relief at day 5 vs day 1, when applied twice daily*.
*Predel HG et al Med Sci Sports Exerc. 2012 Sep;44(9):1629-36
PI available at the bottom of the page.
PI available at the bottom of the page.
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Good answer!
Voltarol 2.32% gel is clinically proven to provide 2x more pain relief at day 5 vs day 1, when applied twice daily*.
*Predel HG et al Med Sci Sports Exerc. 2012 Sep;44(9):1629-36
PI available at the bottom of the page.
PI available at the bottom of the page.
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Wrong answer!
Voltarol 2.32% gel is clinically proven to provide 2x more pain relief at day 5 vs day 1, when applied twice daily*.
*Predel HG et al Med Sci Sports Exerc. 2012 Sep;44(9):1629-36
PI available at the bottom of the page.
PI available at the bottom of the page.
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GAME COMPLETED!
Congratulations, you are a Mythbuster expert!
You have now learnt about how Voltarol 2.32% Gel can provide your patients with musculoskeletal pain relief.
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